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Anti Doping

THE PROHIBITED LIST OF SUSBTANCES AND METHODS

1. Links to the current Prohibited List
2. The 2012 WADA Prohibited List: Summary of Revisions
3. The 2011 WADA Prohibited List: Summary of Revisions
4. The 2010 WADA Prohibited List: Summary of Revisions
5. The 2009 WADA Prohibited List: Summary of Revisions

Links:

2012 Prohibited List
2012 Prohibited List – Summary of Major Modification

The 2012 WADA Prohibited List: Summary of Revisions

The 2012 Prohibited List of Substances and Methods

The ISSF would like to alert all its Shooters and member federations that the World Anti-Doping Agency (WADA) has released the 2012 Prohibited List. The new List comes into effect January 1, 2012.

The ISSF highlights the following noteworthy changes from the 2011 list for all Shooters, ISSF Member Federations and medical staff.

1.       Formoterol added as an exception to beta-2 agonists

One of the most significant changes to the 2012 List is the removal of formoterol from ‘Section 3 Beta-2 Agonists’ of the List when taken by inhalation at therapeutic dosages. Accordingly, in light of recent research results and concerns expressed by members of the sports community, inhaled formoterol at therapeutic doses is no longer prohibited.

The List prohibits the administration of all beta-2 agonists. But under the 2012 List, salbutamol when taken by inhalation (maximum 1600 micrograms over 24 hours), salmeterol when taken by inhalation, and now formoterol when taken by inhalation (maximum 36 micrograms taken over 24 hours) are no longer prohibited.

The issue of beta-2 agonists will continue to be a focus of WADA’s research activity in order to both ensure that the administration of these substances in large doses or by systemic routes is prevented and prohibited, but also that the appropriate care and treatment of asthmatic athletes is facilitated.

2.       Nicotine placed on monitoring program

Under Article 4.5 of the World Anti-Doping Code, WADA is mandated to establish a monitoring program which addresses substances that are not on the List, but which the Agency wishes to monitor in order to detect patterns of misuse.

In order to detect potential patterns of abuse, nicotine has been placed on WADA’s 2012 Monitoring Program. Though it is not WADA’s intention to target smokers, the decision to place nicotine on the monitoring program is to examine the effects nicotine can have on performance when taken orally in tobacco products such as “snus”. 

Nicotine is but one of several stimulants that have been added to the Monitoring Program.  The narcotics hydrocodone and tramadol have also been included as has out-of-competition use of glucocorticosteroids.

3.       Alcohol and beta-blockers

At the request of the Federation Internationale des Quilleurs (FIQ), alcohol is no longer included on the List as a prohibited in-competition substance for ninepin and tenpin bowling.

After a review by WADA and following discussions with stakeholders, bobsleigh and skeleton, curling, modern pentathlon, motorcycling, sailing and wrestling have also been removed from the list of sports included in the List in which beta-blockers are prohibited.

Note that although beta-blockers are no longer prohibited in those specific sports, they are still strictly prohibited in shooting.

4.       Non-approved substances

A non-approved substance is any pharmacological substance which is not addressed by any of the other sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, veterinary medicines). Non-approved substances are prohibited at all times.

The section for non-approved substances – S0 – has been moved under the section for Prohibited Substances to clarify that “methods” are not included in this section.

Furthermore, in order to broaden the scope of this section a word change has been made with “i.e.” being replaced by “e.g.” Additional substances have also been added to this section to clarify its scope. 

Substances will be included in S0 only after all other categories have been considered inadequate. Non-approved substances included in S0, are considered specified.

LINKS:

The 2012 List: http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2012/WADA_Prohibited_List_2012_EN.pdf

The 2012 Monitoring Program, http://www.wada-ama.org/en/World-Anti-Doping-Program/Sports-and-Anti-Doping-Organizations/International-Standards/Prohibited-List/Monitoring-Program/

And

A Q&A on major changes:   http://www.wada-ama.org/en/World-Anti-Doping-Program/Sports-and-Anti-Doping-Organizations/International-Standards/Prohibited-List/QA-on-2012-Prohibited-List/

The 2011 WADA Prohibited List: Summary of Revisions

The ISSF would like to alert all its Shooters and member federations that the World Anti-Doping Agency (WADA) has released the 2011 Prohibited List. The new List comes into effect January 1, 2012.

The ISSF highlights the following noteworthy changes from the 2010 list for all Shooters, ISSF Member Federations and medical staff.

Non-Approved Substances
A new section – “Non-Approved Substances” – has been added. This “open” section addresses the abuse of pharmacological substances for the purpose of performance enhancement which are not included in other sections of the List and which are not approved by any governmental regulatory health authority for human therapeutic use (i.e. drugs under pre-clinical or clinical development or discontinued).

Platelet-Derived Preparations
Platelet-derived preparations (commonly referred as PRP or blood spinning), prohibited in 2010 when administered by intra-muscular route, have been removed from the List for 2011 after consideration of the lack of current evidence concerning the use of these methods for purposes of performance enhancement. Current studies on platelet-derived preparations do not demonstrate a potential for performance enhancement beyond a potential therapeutic effect.

Declaration of Use
The obligation for athletes to file a Declaration of Use for specific substances that are not prohibited has been removed. This change has been reflected accordingly in the 2011 International Standard for Therapeutic Use Exemptions.

The 2010 WADA Prohibited List: Summary of Revisions

The ISSF would like to alert all its Shooters and member federations that the World Anti-Doping Agency (WADA) has released the 2010 Prohibited List. The new List comes into effect January 1, 2010.

The ISSF highlights the following changes for all Shooters, ISSF Member Federations and medical staff.

1. The status of Salbutamol has changed

Following several years of practice and consideration of all relevant information, there has been a change in status of the beta-2 agonist salbutamol, a substance listed as a specified substance in the 2009 List. This is because over the past few years, almost all cases where salbutamol has been detected were covered by Therapeutic Use Exemptions (TUEs).

In the 2010 List, the therapeutic use of inhaled salbutamol will not be prohibited and will therefore no longer require a TUE. For monitoring purposes, Shooters using inhaled salbutamol will be required to declare their use on the Doping Control Form when they are tested or on a separate Declaration of use Form prior to testing to avoid any omissions.

Salbutamol will still be prohibited for urinary concentrations above 1,000 nanograms per milliliter. In such cases, there will be a presumption that the substance was not taken by inhalation and the Shooter will have the burden to demonstrate that the level found in his urine was the result of therapeutic inhaled use.

2. Follow-up testing is no longer necessary for elevated T/E Ratios.

In the past when a Shooter’s sample yielded an elevated testosterone to epitestosterone ratio, at least 2 further tests were necessary to confirm that the source of the elevated T/E ratio was endogenous (natural). As of January 1, 2010, no further collections or analyses will be required in cases where the testosterone to epitestosterone (T/E) ratio of a Shooter is greater than 4 and an isotope ratio mass spectrometry (IRMS) test or any other reliable analytical method has not revealed evidence of exogenous administration of a prohibited substance.

3. Pseudoephedrine is reintroduced on the List.

Until 2003, pseudoephedrine was prohibited in all sports. Then from 2004 on, it was simply annually included in WADA’s Monitoring Program. (The Monitoring Program includes substances that are not prohibited in sport but are monitored by anti-doping laboratories in order to detect patterns of misuse.)

Results of the Monitoring Program over the past five years have shown a sustained increase in samples containing pseudoephedrine, a clear abuse of this substance with high concentrations in a number of sports and regions, and scientific evidence of the performance-enhancing effects of pseudoephedrine beyond certain doses. Based on theses results pseudoephedrine will be prohibited above 150 micrograms per milliliter.

4. Supplement oxygen for medical reasons is not prohibited

The 2010 List clarifies that supplemental oxygen (hyperoxia) is not prohibited.

5. Platelet-Derived Preparations prohibited when administered via muscles.

The status of platelet-derived preparations (e.g. Platelet Rich Plasma, “blood spinning”) has been clarified. These preparations will be prohibited when administered by intramuscular route. Other routes of administration will require a Declaration of Use in compliance with the International Standard for TUEs.

Links:
Prohibited List 2010 - PDF
Summary of modifications 2010 - PDF

The 2009 WADA Prohibited List: Summary of Revisions

The ISSF would like to alert all its Shooters and member federations that the World Anti-Doping Agency (WADA) has released the 2009 Prohibited List. The new List comes into effect January 1, 2009.

WADA has summarized the differences from the 2008 list in an explanatory note. The ISSF would like to highlight certain changes for all Shooters.

1. Athletes that use the prohibited substances found in asthma medications for medically justified reasons will follow a different approval process.

The Abbreviated Therapeutic Use Exemption (ATUE) process has been discontinued. Athletes that use beta-2 agonists and glucocorticosteroids will see a new combination of declarations through ADAMS and on their doping control form, and a requirement to maintain a medical file that supports the use of the substance. The file is to be submitted to either the ISSF or to their NADO (National Anti-Doping Organisation), either in advance of competition or retroactively upon request. A variety of factors, such as the athlete’s level and the route of administration, determine the exact process. We advise you to contact the ISSF or your NADO for more information.

2. A large number of substances on the Prohibited List have been reclassified as “specified substances” because they are considered to be generally available in medicinal products or less likely to be abused as doping agents.

Only anabolic agents and hormones, some stimulants, certain hormone antagonists and modulators, and all prohibited methods are NOT in this category. The effect of this change will be primarily reflected in the results management process, when the duration of a sanction will be determined from within a range of time based on the factors pertinent to each case.

3. Alpha reductase inhibitors are no longer prohibited

They have been rendered ineffective as masking agents by closer consideration of steroid profiles. An example of these types of inhibitors is finasteride, which is commonly used in the treatment of male pattern baldness and is currently sold in many countries under the brand names Propecia and Proscar.

4. Intravenous infusions are still prohibited and require a TUE, but a list of exceptions is provided.

The list of non-prohibited medical uses of intravenous infusions includes the management of surgical procedures, medical emergencies or clinical investigations, and injections with a simple syringe if the substance is not prohibited and is less than 50 ml.