The World Anti-Doping Agency (WADA) published the 2021 List of Prohibited Substances and Methods (List); the 2021 Summary of Major Modifications and Explanatory Notes; and the 2021 Monitoring Program. The 2021 List, which has been redesigned in order to improve navigation and usability for athletes and their support personnel, was approved by WADA’s Executive Committee (ExCo) during its meeting on 14-15 September 2020 and comes into force on 1 January 2021.